DMPS

• Mercury is toxic to the body cell


• Therefore, if mercury is found in human body, it has to be removed


• Doctors will administer the sodium salt of DMPS (Unithiol) as medicine to the patients with mercury poisoning


• In the body, the sodium salt of DMPS complex will dissociate into sodium and DMPS


• DMPS will form a coordination compound with mercury = [DMPS]2Hg


• This is because DMPS is a chelating agent which contains 2 SH groups (di-thiol)


• Hg ion has great affinity for SH groups of endogenous biomolecules, which may contribute to its toxicity


• Since DMPS has 2 SH groups, injection of the DMPS can bind tightly to Hg


• The product of this compound ([DMPS]2Hg) will be eliminate from the body through the excretion system

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